Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.83 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557736 | 0.95 | KCNH2 (0.83) | KCNH2SLC6A2SLC6A4SLC6A3SCN5A | |
| SCHEMBL8554712 | 0.91 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3SCN5A | |
| SCHEMBL8556398 | 0.91 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3SCN5A | |
| SCHEMBL8555810 | 0.91 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3SCN5A | |
| SCHEMBL8864698 | 0.88 | KCNH2 (0.83) | KCNH2SLC6A2SLC6A4SLC6A3SCN5A | |
| SCHEMBL8553316 | 0.88 | KCNH2 (0.83) | KCNH2SLC6A2SLC6A4SLC6A3SCN5A | |
| Hydrochloric Acid SCHEMBL8864716 | 0.87 | KCNH2 (0.81) | KCNH2SLC6A2SLC6A4SLC6A3SCN5A | |
| SCHEMBL8554877 | 0.84 | KCNH2 (0.77) | KCNH2SCN5A | |
| SCHEMBL8553978 | 0.83 | KCNH2 (0.83) | KCNH2SCN5A | |
| SCHEMBL8865127 | 0.83 | KCNH2 (0.74) | KCNH2ALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0475527-B1 | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | SANOFI SA (FR) | 1998-02-25 | — | — | EP | claimed |
| EP-0475527-A2 | Aryl-fused and hetaryl-fused-2, 4-diazepine and 2, 4-diazocine antiarrhythmic agents | STERLING DRUG INC. (US) | 1992-03-18 | — | — | EP | claimed |
| EP-0475527-B1 | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | SANOFI SA (FR) | 1998-02-25 | — | — | EP | disclosed |