Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.83 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554225 | 0.95 | KCNH2 (0.83) | KCNH2SLC6A2SLC6A4SLC6A3SCN5A | |
| SCHEMBL8556398 | 0.91 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3SCN5A | |
| SCHEMBL8555810 | 0.91 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3SCN5A | |
| SCHEMBL8554712 | 0.91 | KCNH2 (1.00) | KCNH2SLC6A2SLC6A4SLC6A3SCN5A | |
| SCHEMBL8553978 | 0.88 | KCNH2 (0.83) | KCNH2SCN5A | |
| SCHEMBL8557731 | 0.85 | KCNH2 (0.74) | KCNH2 | |
| SCHEMBL8554877 | 0.84 | KCNH2 (0.77) | KCNH2SCN5A | |
| SCHEMBL8864698 | 0.83 | KCNH2 (0.83) | KCNH2SLC6A2SLC6A4SLC6A3SCN5A | |
| SCHEMBL8553316 | 0.83 | KCNH2 (0.83) | KCNH2SLC6A2SLC6A4SLC6A3SCN5A | |
| Hydrochloric Acid SCHEMBL8864716 | 0.82 | KCNH2 (0.81) | KCNH2SLC6A2SLC6A4SLC6A3SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0475527-B1 | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | SANOFI SA (FR) | 1998-02-25 | — | — | EP | claimed |
| EP-0475527-A2 | Aryl-fused and hetaryl-fused-2, 4-diazepine and 2, 4-diazocine antiarrhythmic agents | STERLING DRUG INC. (US) | 1992-03-18 | — | — | EP | claimed |
| EP-0475527-B1 | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | SANOFI SA (FR) | 1998-02-25 | — | — | EP | disclosed |