Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.77 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553978 | 0.96 | KCNH2 (0.83) | KCNH2SCN5AESR1ESR2 | |
| SCHEMBL8553316 | 0.96 | KCNH2 (0.83) | KCNH2SCN5A | |
| Hydrochloric Acid SCHEMBL8864652 | 0.92 | KCNH2 (0.69) | KCNH2SCN5A | |
| SCHEMBL8555810 | 0.87 | KCNH2 (1.00) | KCNH2SCN5A | |
| SCHEMBL8554712 | 0.87 | KCNH2 (1.00) | KCNH2SCN5A | |
| SCHEMBL8556398 | 0.87 | KCNH2 (1.00) | KCNH2SCN5A | |
| SCHEMBL8864698 | 0.84 | KCNH2 (0.83) | KCNH2SCN5A | |
| SCHEMBL8554225 | 0.84 | KCNH2 (0.83) | KCNH2SCN5A | |
| SCHEMBL8557736 | 0.84 | KCNH2 (0.83) | KCNH2SCN5A | |
| Hydrochloric Acid SCHEMBL8864716 | 0.83 | KCNH2 (0.81) | KCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0475527-B1 | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | SANOFI SA (FR) | 1998-02-25 | — | — | EP | disclosed |
| US-5624922-A | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1997-04-29 | — | — | US | disclosed |
| EP-0597540-B1 | Aryl-fused and hetaryl-fused-2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC (US) | 1996-06-05 | — | — | EP | disclosed |
| US-5380721-A | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0597540-A1 | Aryl-fused and hetaryl-fused-2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1994-05-18 | — | — | EP | disclosed |
| EP-0475527-A2 | Aryl-fused and hetaryl-fused-2, 4-diazepine and 2, 4-diazocine antiarrhythmic agents | STERLING DRUG INC. (US) | 1992-03-18 | — | — | EP | disclosed |