Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559774 | 0.85 | RAB9A (0.56) | PDE10APDE3BPDE3ARAB9ASMN1; SMN2 | |
| SCHEMBL1446506 | 0.83 | GAA (0.53) | PDE10APDE3BPDE3ARAB9ASMN1; SMN2 | |
| SCHEMBL23457928 | 0.83 | RAB9A (0.50) | PDE10APDE3BPDE3ARAB9ASMN1; SMN2 | |
| SCHEMBL10867414 | 0.80 | RAB9A (0.58) | PDE10APDE3BPDE3ARAB9ASMN1; SMN2 | |
| SCHEMBL1445588 | 0.79 | PDE10A (0.66) | PDE10APDE3BPDE3ARAB9ASMN1; SMN2 | |
| SCHEMBL1445580 | 0.78 | PDE10A (0.51) | PDE10APDE3BPDE3ARAB9ASMN1; SMN2 | |
| SCHEMBL4429531 | 0.78 | PDE10A (0.75) | PDE10APDE3BPDE3ARAB9ASMN1; SMN2 | |
| SCHEMBL1445418 | 0.78 | POLB (0.43) | PDE10APDE3BPDE3ARAB9ASMN1; SMN2 | |
| SCHEMBL23459855 | 0.78 | MTNR1A (0.51) | PDE10APDE3BPDE3ARAB9A | |
| SCHEMBL8554954 | 0.78 | PDE10A (0.53) | PDE10APDE3BPDE3ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0617022-B1 | 6,7, dialkoxy-3,4-dihydroisoquinolin-8-ol, process for preparation thereof and process for preparation of 6,7-dialkoxy-1,2,3,4-tetrahydroisoquinolin-8-ol using the compound | BANYU PHARMA CO LTD (JP) | 1998-02-11 | — | — | EP | disclosed |
| EP-0617022-A1 | 6,7, dialkoxy-3,4-dihydroisoquinolin-8-ol, process for preparation thereof and process for preparation of 6,7-dialkoxy-1,2,3,4-tetrahydroisoquinolin-8-ol using the compound | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1994-09-28 | — | — | EP | disclosed |