Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.40 |
| ▸ | CPT1A | P50416 | 1/20 | 0.40 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553118 | 0.85 | ALOX5 (0.53) | PARP1ALDH1A1ALOX5CHRM4GRIN2D | |
| SCHEMBL8554233 | 0.81 | ALOX5 (0.53) | PARP1KDM4ESMN1; SMN2HTTKMT2A | |
| SCHEMBL9304651 | 0.76 | CDK4 (0.44) | KDM4EKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL9304984 | 0.75 | ALOX5 (0.45) | PARP1KDM4ESMN1; SMN2HTTKMT2A | |
| SCHEMBL8595965 | 0.75 | ALOX5 (0.52) | ALOX5CHRM4GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8554785 | 0.74 | ALOX5 (0.49) | ALOX5CHRM4GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8552282 | 0.73 | ALOX5 (0.59) | PARP1KDM4ESMN1; SMN2HTTCPT2 | |
| Hydrochloric Acid SCHEMBL8557808 | 0.73 | ALOX5 (0.48) | ALOX5CHRM4GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8553755 | 0.73 | PARP1 (0.47) | PARP1KDM4ESMN1; SMN2HTTKMT2A | |
| SCHEMBL8556109 | 0.71 | ALOX5 (0.51) | PARP1ALDH1A1ALOX5CHRM4GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0529452-B1 | 1,7-Condensed 3-(piperazinoalkyl)indol derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SOLVAY PHARM GMBH (DE) | 1998-11-11 | — | — | EP | disclosed |
| EP-0529452-A2 | 1,7-Condensed 2-(piperazinoalkyl)indol derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | Kali-Chemie Pharma GmbH (DE) | 1993-03-03 | — | — | EP | disclosed |