SCHEMBL8554518

SCHEMBL8554518

COC(=O)CC[C@H]1CC[C@H](NC(=O)c2cn(C3CCN(C(=O)OC(C)(C)C)CC3)cn2)CC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.47
POLB P06746 2/20 0.41
PARP1 P09874 2/20 0.40
USP30 Q70CQ3 4/20 0.40
MEN1 O00255 2/20 0.40
ALDH1A1 P00352 2/20 0.40
KMT2A Q03164 2/20 0.40
HDAC4 P56524 1/20 0.40
FAAH O00519 1/20 0.40
CCNA2 P20248 2/20 0.40
CDK2 P24941 2/20 0.40
CDK5 Q00535 2/20 0.40
CDK5R1 Q15078 2/20 0.40
EPHX1 P07099 1/20 0.39
MAPT P10636 1/20 0.39
MAPK1 P28482 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
CNR2 P34972 1/20 0.39
KDM4E B2RXH2 1/20 0.39
PKM P14618 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8657208 0.84 SMYD3 (0.41) ALDH1A1
Hydrochloric Acid SCHEMBL8591588 0.84 SMYD3 (0.41) ALDH1A1
SCHEMBL8550973 0.78 GPR119 (0.51) ALDH1A1EPHX1
SCHEMBL8549340 0.78 GPR119 (0.40) L3MBTL1ALDH1A1FAAH
SCHEMBL8594911 0.76 NR3C1 (0.47) MEN1ALDH1A1KMT2AMAPT
SCHEMBL8623093 0.76 GPR119 (0.49) MAPTKDM4EPKM
SCHEMBL9409500 0.76 HDAC4 (0.48) L3MBTL1POLBKMT2AHDAC4KDM4E
SCHEMBL9409402 0.75 EPHX2 (0.45) L3MBTL1POLBPARP1MEN1ALDH1A1
SCHEMBL8549754 0.75 SMYD3 (0.45) L3MBTL1POLBPARP1USP30MEN1
SCHEMBL594491 0.74 KDM4E (0.51) ALDH1A1FAAHEPHX1KDM4EPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0858457-A1 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM Dr. Karl Thomae GmbH (DE) 1998-08-19 EP disclosed
WO-1997015567-A1 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM DR. KARL THOMAE GMBH (DE) 1997-05-01 WO disclosed