Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | TLR4 | O00206 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8293162 | 0.91 | ALDH1A1 (0.43) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL5419363 | 0.90 | ALDH1A1 (0.42) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL4080364 | 0.73 | ALDH1A1 (0.51) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL19360209 | 0.72 | ALDH1A1 (0.53) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL22174706 | 0.70 | MEN1 (0.51) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL27272040 | 0.70 | CYP3A4 (0.44) | MAPTALDH1A1KDM4EGAASMN1; SMN2 | |
| SCHEMBL4077853 | 0.70 | TLR4 (0.55) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL14810505 | 0.70 | ALDH1A1 (0.43) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11676787 | 0.69 | CYP3A4 (0.43) | MAPTALDH1A1KDM4EGAASMN1; SMN2 | |
| SCHEMBL3913430 | 0.68 | MEN1 (0.52) | MAPTALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544773-B1 | AZABICYCLIC COMPOUNDS, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1998-03-18 | — | — | EP | disclosed |
| US-5362739-A | Acetylcholine activators, dementia treatment | BEECHAM GROUP P.L.C. (GB) | 1994-11-08 | — | — | US | disclosed |
| WO-1992003435-A1 | AZABICYCLIC COMPOUNDS, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1992-03-05 | — | — | WO | disclosed |