Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PPM1B | O75688 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4080364 | 0.92 | ALDH1A1 (0.51) | TLR4ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL5659584 | 0.89 | TLR4 (0.50) | TLR4ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL8187713 | 0.88 | TLR4 (0.49) | TLR4ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL1617437 | 0.88 | TLR4 (0.49) | TLR4ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL25014921 | 0.86 | TLR4 (0.48) | TLR4ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL5896856 | 0.85 | TLR4 (0.47) | TLR4ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL3965799 | 0.84 | TLR4 (0.46) | TLR4ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL3967641 | 0.84 | TLR4 (0.46) | TLR4ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL13883455 | 0.82 | TLR4 (0.45) | TLR4ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL3081279 | 0.82 | LMNA (0.47) | TLR4ALDH1A1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049018-A1 | NOVEL COMPOUNDS AND METHODS OF USING THEM | SYNDAX PHARMACEUTICALS, INC. (US) | 2009-04-16 | — | — | WO | disclosed |