Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 13/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10816361 | 0.80 | CHRM2 (0.44) | MTNR1ACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL8553144 | 0.79 | CHRM2 (0.43) | MTNR1ACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL13068286 | 0.76 | DRD2 (0.41) | CHRM2CHRM4CHRM1DRD2CHRM3 | |
| SCHEMBL28430539 | 0.76 | DRD2 (0.41) | CHRM2CHRM4CHRM1DRD2CHRM3 | |
| SCHEMBL9685608 | 0.74 | TSHR (0.41) | TSHRPOLBGAASMN1; SMN2 | |
| SCHEMBL1473250 | 0.72 | PLAU (0.44) | CHRM2CHRM1DRD3TSHRGAA | |
| SCHEMBL8071751 | 0.72 | HTR2A (0.43) | TSHRGAASMN1; SMN2 | |
| SCHEMBL9396982 | 0.70 | GAA (0.50) | CHRM2CHRM4CHRM1DRD2CHRM3 | |
| SCHEMBL9470084 | 0.70 | MTNR1A (0.59) | MTNR1ACHRM2CHRM4CHRM1DRD2 | |
| SCHEMBL11795278 | 0.69 | MTNR1A (0.55) | MTNR1AMTNR1BCHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0529452-B1 | 1,7-Condensed 3-(piperazinoalkyl)indol derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SOLVAY PHARM GMBH (DE) | 1998-11-11 | — | — | EP | disclosed |
| US-5324725-A | Antiinflammatory agent, antiallergen | KALI-CHEMIE PHARMA GMBH (DE) | 1994-06-28 | — | — | US | disclosed |
| EP-0529452-A2 | 1,7-Condensed 2-(piperazinoalkyl)indol derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | Kali-Chemie Pharma GmbH (DE) | 1993-03-03 | — | — | EP | disclosed |