Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 11/20 | 0.62 |
| ▸ | RXRA | P19793 | 6/20 | 0.45 |
| ▸ | RXRB | P28702 | 5/20 | 0.45 |
| ▸ | RXRG | P48443 | 2/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.39 |
| ▸ | NR4A3 | Q92570 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546270 | 0.90 | NR4A2 (0.49) | NR4A2RXRARXRBRXRGFAAH | |
| SCHEMBL8555990 | 0.90 | NR4A2 (0.62) | NR4A2RXRARXRBRXRGFAAH | |
| SCHEMBL8560591 | 0.87 | NR4A2 (0.46) | NR4A2RXRARXRBRXRGFAAH | |
| SCHEMBL8556797 | 0.84 | ALDH1A1 (0.46) | NR4A2RXRARXRBRXRGKDM4E | |
| SCHEMBL5694182 | 0.81 | PTGS2 (0.56) | NR4A2RXRARXRBCA1CA2 | |
| SCHEMBL8557634 | 0.81 | NR4A2 (0.66) | NR4A2RXRARXRBRXRGKDM4E | |
| SCHEMBL8547540 | 0.81 | NR4A2 (0.49) | NR4A2RXRARXRBRXRGKDM4E | |
| Methane SCHEMBL6310045 | 0.80 | USP1 (0.48) | NR4A2RXRARXRBKDM4EALDH1A1 | |
| SCHEMBL7502759 | 0.80 | NR4A2 (0.73) | NR4A2RXRARXRBRXRGCA1 | |
| SCHEMBL7500800 | 0.80 | NR4A2 (0.73) | NR4A2RXRARXRBRXRGCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |