Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | PRKX | P51817 | 1/20 | 0.35 |
| ▸ | NEK2 | P51955 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556437 | 0.89 | CHEK1 (0.42) | KDM4ELMNAMEN1RECQLKMT2A | |
| SCHEMBL8557555 | 0.81 | PDE5A (0.45) | TP53CHEK1DAPK3PRKD3MET | |
| SCHEMBL8559120 | 0.81 | ADORA3 (0.50) | ADORA3 | |
| SCHEMBL8553483 | 0.80 | CHEK1 (0.43) | MEN1KMT2AALDH1A1CHEK1DAPK3 | |
| SCHEMBL8558977 | 0.79 | PDE5A (0.38) | CHEK1DAPK3PRKD3METPDGFRA | |
| SCHEMBL8557418 | 0.78 | PDE5A (0.49) | MEN1KMT2AALDH1A1ADORA3CYP3A4 | |
| SCHEMBL8553821 | 0.78 | POLB (0.49) | KDM4EMEN1KMT2AALDH1A1ADORA3 | |
| SCHEMBL8557905 | 0.78 | GRIN2D (0.43) | CHEK1DAPK3PRKD3METPDGFRA | |
| SCHEMBL8557421 | 0.78 | EGLN1 (0.38) | KDM4EKMT2AGAACHEK1DAPK3 | |
| SCHEMBL8554013 | 0.78 | ADORA3 (0.46) | KDM4EMEN1KMT2AGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691970-B1 | IMIDAZOLOQUINOXALINONE DERIVATIVES AS EAA ANTAGONISTS | BASF AG (DE) | 1998-11-11 | — | — | EP | disclosed |