Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.30 |
| ▸ | CHRNG | P07510 | 1/20 | 0.30 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | CHRND | Q07001 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27540488 | 1.00 | HCAR3 (0.34) | HCAR3HCAR2SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL12638735 | 0.84 | OPRK1 (0.41) | SLC6A2SLC6A4 | |
| SCHEMBL9229582 | 0.84 | OPRK1 (0.41) | SLC6A2SLC6A4 | |
| SCHEMBL8556195 | 0.83 | SLC6A2 (0.45) | HCAR3HCAR2SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL8557006 | 0.82 | HCAR3 (0.32) | HCAR3HCAR2SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL8557008 | 0.82 | HCAR3 (0.32) | HCAR3HCAR2SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL7814915 | 0.77 | KMT2A (0.35) | HCAR3HCAR2SLC6A3SLC6A4 | |
| SCHEMBL7802557 | 0.77 | KMT2A (0.35) | HCAR3HCAR2SLC6A3SLC6A4 | |
| SCHEMBL7802560 | 0.77 | KMT2A (0.35) | HCAR3HCAR2SLC6A3SLC6A4 | |
| SCHEMBL9380130 | 0.76 | ALOX5 (0.33) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623614-B1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1998-02-25 | — | — | EP | disclosed |
| US-5512594-A | ADMINISTERING TO TREAT A MEDICAL CONDITION MEDIATED BY ONE OR MORE LEUKOTRIENES | ZENECA LIMITED (GB) | 1996-04-30 | — | — | US | disclosed |
| EP-0702678-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-03-27 | — | — | EP | disclosed |
| US-5478842-A | Antiinflammatory agents, antiallergens, drugs for treatment of diseases mediated by leukotrienes | ZENECA LIMITED (GB) | 1995-12-26 | — | — | US | disclosed |
| WO-1995030668-A1 | CYCLIC ETHER DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | ZENECA LIMITED (GB) | 1995-11-16 | — | — | WO | disclosed |
| WO-1994029291-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1994-12-22 | — | — | WO | disclosed |
| WO-1994025453-A1 | 4-ARYL-4-HYDROXY-TETRAHYDROPYRANS AND 3-ARYL-3-HYDROXY-TETRAHYDROFURANS AS 5-LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |
| EP-0623614-A1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1994-11-09 | — | — | EP | disclosed |