Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6190765 | 0.80 | SMN1; SMN2 (0.33) | SMN1; SMN2RAB9ANPC1HPGDALDH1A1 | |
| SCHEMBL3665973 | 0.78 | — | — | |
| SCHEMBL5050109 | 0.73 | SMN1; SMN2 (0.32) | SMN1; SMN2RAB9ANPC1ALDH1A1GAA | |
| SCHEMBL5951665 | 0.73 | DPP4 (0.39) | SMN1; SMN2RAB9ANPC1HPGDALDH1A1 | |
| SCHEMBL14645264 | 0.73 | HPGD (0.36) | SMN1; SMN2RAB9ANPC1HPGDALDH1A1 | |
| SCHEMBL28354380 | 0.71 | MMP1 (0.33) | — | |
| SCHEMBL1186594 | 0.70 | — | — | |
| SCHEMBL38298 | 0.69 | — | — | |
| SCHEMBL526171 | 0.69 | CES2 (0.39) | SMN1; SMN2RAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL19665079 | 0.69 | ERN1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880507-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ZENECA LIMITED (GB) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997030034-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ZENECA LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |