Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | TPO | P07202 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8596089 | 0.98 | CYP3A4 (0.42) | HTR2AHRH1MPOTPOCYP3A4 | |
| Hydrochloric Acid SCHEMBL8865235 | 0.85 | CYP3A4 (0.37) | CYP3A4KDM4EMAPTSLC6A4SLC6A2 | |
| Hydrochloric Acid SCHEMBL8864613 | 0.83 | SLC6A4 (0.54) | CYP3A4KDM4ESLC6A4SLC6A2SLC6A3 | |
| SCHEMBL8558826 | 0.81 | MPO (0.38) | HRH1MPOTPOKDM4ESLC6A4 | |
| SCHEMBL8958232 | 0.79 | OPRM1 (0.42) | HTR2AMPOTPOTAAR1SLC6A4 | |
| SCHEMBL28200881 | 0.79 | MAPT (0.45) | HTR2AHRH1CYP3A4KDM4EMAPT | |
| SCHEMBL8552541 | 0.78 | TACR1 (0.37) | HTR2AHRH1MPOTPOKDM4E | |
| Hydrochloric Acid SCHEMBL28200249 | 0.77 | MAPT (0.47) | HTR2AHRH1CYP3A4KDM4EMAPT | |
| SCHEMBL8558251 | 0.77 | TAAR1 (0.43) | HTR2AHRH1MPOTPOTAAR1 | |
| SCHEMBL8556619 | 0.76 | KDM4E (0.46) | CYP3A4KDM4EMAPTTAAR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0475527-A2 | Aryl-fused and hetaryl-fused-2, 4-diazepine and 2, 4-diazocine antiarrhythmic agents | STERLING DRUG INC. (US) | 1992-03-18 | — | — | EP | claimed |
| EP-0475527-B1 | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | SANOFI SA (FR) | 1998-02-25 | — | — | EP | disclosed |
| US-5639904-A | CARDIOVASCULAR DISORDERS | PRODESFARMA, S.A. (ES) | 1997-06-17 | — | — | US | disclosed |
| US-5624922-A | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1997-04-29 | — | — | US | disclosed |
| EP-0597540-B1 | Aryl-fused and hetaryl-fused-2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC (US) | 1996-06-05 | — | — | EP | disclosed |
| US-5502237-A | VASODILATORS, ADRENERGIC BLOCKING AGENTS | PRODESFARMA, S. A. (ES) | 1996-03-26 | — | — | US | disclosed |
| EP-0637583-A1 | 1-Aryloxy-3-alkylamino-2-propanol nitrate esters, the use thereof and corresponding pharmaceutical composition | PRODESFARMA, S.A. (ES) | 1995-02-08 | — | — | EP | disclosed |
| US-5380721-A | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0597540-A1 | Aryl-fused and hetaryl-fused-2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1994-05-18 | — | — | EP | disclosed |
| EP-0475527-A2 | Aryl-fused and hetaryl-fused-2, 4-diazepine and 2, 4-diazocine antiarrhythmic agents | STERLING DRUG INC. (US) | 1992-03-18 | — | — | EP | disclosed |
| US-4621088-A | N-acyl derivatives of amino acids and their esters, and drugs in which they are present | PANMEDICA (FR) | 1986-11-04 | — | — | US | disclosed |