Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 3/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | TPO | P07202 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8865240 | 0.98 | TAAR1 (0.41) | TAAR1HTR2ADPP4F2HRH1 | |
| SCHEMBL8958232 | 0.82 | OPRM1 (0.42) | TAAR1HTR2ADPP4F2MPO | |
| SCHEMBL9719141 | 0.79 | DPP4 (0.55) | TAAR1HTR2ADPP4F2 | |
| SCHEMBL7985396 | 0.79 | TDP1 (0.39) | TAAR1HTR2ADPP4F2MPO | |
| SCHEMBL8183495 | 0.78 | MEN1 (0.44) | TAAR1HTR2ADPP4HRH1PNMT | |
| SCHEMBL8555524 | 0.77 | HTR2A (0.40) | TAAR1HTR2ADPP4F2HRH1 | |
| SCHEMBL17871883 | 0.77 | SLC6A4 (0.48) | HTR2AHRH1 | |
| Hydrochloric Acid SCHEMBL8596089 | 0.76 | CYP3A4 (0.42) | TAAR1HTR2AHRH1MPOTPO | |
| SCHEMBL15338507 | 0.74 | PNMT (0.43) | TAAR1DPP4PNMT | |
| SCHEMBL8552541 | 0.73 | TACR1 (0.37) | TAAR1HTR2ADPP4HRH1MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0475527-B1 | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | SANOFI SA (FR) | 1998-02-25 | — | — | EP | disclosed |
| US-5624922-A | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1997-04-29 | — | — | US | disclosed |
| EP-0597540-B1 | Aryl-fused and hetaryl-fused-2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC (US) | 1996-06-05 | — | — | EP | disclosed |
| US-5380721-A | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0597540-A1 | Aryl-fused and hetaryl-fused-2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1994-05-18 | — | — | EP | disclosed |
| EP-0475527-A2 | Aryl-fused and hetaryl-fused-2, 4-diazepine and 2, 4-diazocine antiarrhythmic agents | STERLING DRUG INC. (US) | 1992-03-18 | — | — | EP | disclosed |