Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 14/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CCR6 | P51684 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556979 | 0.90 | PTGS2 (0.61) | PTGS2PTGS1SMN1; SMN2TDP1CYP1A2 | |
| SCHEMBL6025799 | 0.76 | PTGS2 (0.68) | PTGS2PTGS1 | |
| SCHEMBL215744 | 0.76 | PTGS2 (0.64) | PTGS2PTGS1NR4A2 | |
| SCHEMBL216233 | 0.76 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL7503718 | 0.76 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL19953600 | 0.76 | PTGS2 (0.75) | PTGS2PTGS1 | |
| SCHEMBL5698709 | 0.76 | PTGS2 (0.75) | PTGS2PTGS1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7500353 | 0.75 | PTGS2 (0.67) | PTGS2PTGS1 | |
| SCHEMBL9029716 | 0.75 | PTGS2 (0.59) | PTGS2PTGS1 | |
| SCHEMBL7511025 | 0.74 | PTGS2 (0.65) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |