Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.36 |
| ▸ | PARP1 | P09874 | 3/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560804 | 0.81 | BRD4 (0.37) | BRD4CREBBPPARP1MAOA | |
| SCHEMBL8558219 | 0.79 | — | — | |
| SCHEMBL23501955 | 0.68 | PGR (0.33) | BRD4CREBBP | |
| SCHEMBL8558415 | 0.64 | — | — | |
| SCHEMBL17066904 | 0.62 | ALDH1A1 (0.51) | MAOA | |
| SCHEMBL9094745 | 0.61 | BRD4 (0.39) | BRD4CREBBPPARP1 | |
| SCHEMBL23835758 | 0.59 | PGR (0.43) | BRD4CREBBP | |
| SCHEMBL23501934 | 0.59 | PGR (0.38) | MAOA | |
| SCHEMBL18768108 | 0.59 | AKR1B1 (0.43) | BRD4CREBBPPARP1MAOA | |
| SCHEMBL28331547 | 0.58 | RAB9A (0.44) | PARP1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653426-B1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA CO (JP) | 1998-07-22 | — | — | EP | disclosed |
| US-5510366-A | INOTROPIC, ANTIARRHYMTHMIA AGENTS, VASODILATORS | KOWA CO., LTD. (JP) | 1996-04-23 | — | — | US | disclosed |
| EP-0653426-A1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA COMPANY, LTD. (JP) | 1995-05-17 | — | — | EP | disclosed |