SCHEMBL8555721

SCHEMBL8555721

O=C(Cl)c1cccnc1C(=O)Oc1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.56
ALOX15 P16050 2/20 0.47
HSD17B10 Q99714 2/20 0.47
HPGD P15428 1/20 0.47
MAPT P10636 5/20 0.46
KDM4E B2RXH2 4/20 0.46
TSHR P16473 2/20 0.46
CYP3A4 P08684 1/20 0.46
BLM P54132 1/20 0.46
AGER Q15109 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
TDP1 Q9NUW8 4/20 0.46
LMNA P02545 2/20 0.45
KMT2A Q03164 4/20 0.41
POLB P06746 2/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
MEN1 O00255 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C9 P11712 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL69045 0.89 ALDH1A1 (0.65) ALDH1A1ALOX15HSD17B10HPGDMAPT
SCHEMBL2372518 0.79 L3MBTL1 (0.57) ALDH1A1ALOX15MAPTKDM4ETSHR
SCHEMBL9275469 0.78 KDM4E (0.74) ALDH1A1ALOX15MAPTKDM4ETSHR
SCHEMBL9225575 0.78 HSD17B10 (0.63) ALDH1A1ALOX15HSD17B10HPGDMAPT
SCHEMBL10900815 0.78 ALDH1A1 (0.63) ALDH1A1ALOX15HSD17B10HPGDMAPT
SCHEMBL980115 0.78 ALDH1A1 (0.63) ALDH1A1ALOX15HSD17B10HPGDMAPT
SCHEMBL890368 0.77 KDM4E (0.55) ALDH1A1ALOX15MAPTKDM4ETSHR
Hydrochloric Acid SCHEMBL28182285 0.76 KDM4E (0.53) ALDH1A1ALOX15MAPTKDM4ETSHR
SCHEMBL4069169 0.75 MAPT (0.45) ALDH1A1ALOX15MAPTKDM4ETSHR
SCHEMBL1086604 0.74 ALDH1A1 (0.70) ALDH1A1MAPTKDM4ETDP1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0876369-A1 2- 2- (2-HYDROXYETHYL)AMINO]ETHYL]-5- 2-METHYLAMINO)ETHYL]AMINO]INDAZOLO 4,3-gh]ISOQUINOLIN-6(2H)-ONE AS ANTITUMOR AGENT BOEHRINGER MANNHEIM ITALIA S.p.A. (IT) 1998-11-11 EP claimed
WO-1997010245-A1 2-[2-[(2-HYDROXYETHYL)AMINO]ETHYL]-5-[[2-METHYLAMINO)ETHYL]AMINO]INDAZOLO[4,3-gh]ISOQUINOLIN-6(2H)-ONE AS ANTITUMOR AGENT BOEHRINGER MANNHEIM ITALIA S.P.A. (IT) 1997-03-20 WO claimed