Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.46 |
| ▸ | RXRB | P28702 | 2/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558684 | 0.95 | RXRA (0.46) | RXRARXRBNR4A2NPC1RAB9A | |
| SCHEMBL8556259 | 0.92 | NPC1 (0.41) | RXRARXRBNR4A2NPC1RAB9A | |
| SCHEMBL8555050 | 0.90 | NPC1 (0.39) | RXRARXRBNR4A2NPC1RAB9A | |
| SCHEMBL8556349 | 0.90 | RXRA (0.38) | RXRARXRBNR4A2NPC1RAB9A | |
| SCHEMBL8560361 | 0.90 | RXRA (0.46) | RXRARXRBNR4A2NPC1RAB9A | |
| SCHEMBL8558356 | 0.88 | FABP1 (0.38) | RXRARXRBNR4A2NPC1RAB9A | |
| SCHEMBL8553816 | 0.88 | MAPT (0.40) | RXRARXRBNR4A2NPC1RAB9A | |
| SCHEMBL8556756 | 0.88 | NPC1 (0.39) | RXRARXRBNR4A2NPC1RAB9A | |
| SCHEMBL8559272 | 0.87 | NPC1 (0.38) | RXRARXRBNR4A2NPC1RAB9A | |
| SCHEMBL8561044 | 0.87 | NPC1 (0.38) | RXRARXRBNR4A2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |