Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558973 | 0.79 | HPGD (0.44) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL8555923 | 0.74 | PDE2A (0.44) | PDE2AKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL9822430 | 0.68 | PDE2A (0.42) | PDE2ANPC1RAB9AKMT2AMEN1 | |
| SCHEMBL9822411 | 0.68 | PDE2A (0.42) | PDE2ANPC1RAB9AKMT2AMEN1 | |
| SCHEMBL10463310 | 0.66 | ALDH1A1 (0.41) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL18122671 | 0.64 | POLB (0.47) | NPC1RAB9AKMT2AMEN1KDM4E | |
| SCHEMBL18459329 | 0.64 | CA2 (0.61) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL9842102 | 0.63 | ALDH1A1 (0.41) | KMT2AKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL9841866 | 0.61 | CA2 (0.43) | ALDH1A1MAPTSMN1; SMN2TDP1 | |
| SCHEMBL9841876 | 0.61 | ALDH1A1 (0.40) | KMT2AMEN1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591528-B1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE AND ANTI-INFLAMMATORY CONTAINING THE SAME | OTSUKA PHARMA CO LTD (JP) | 1998-12-23 | — | — | EP | disclosed |
| US-5688949-A | CYCLOOXYGENASE INHIBITORS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1997-11-18 | — | — | US | disclosed |
| EP-0591528-A1 | PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVE AND ANTI-INFLAMMATORY CONTAINING THE SAME | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1994-04-13 | — | — | EP | disclosed |