Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843954 | 0.82 | ALDH1A1 (0.37) | ALDH1A1GAATDP1SMN1; SMN2CA2 | |
| SCHEMBL9842102 | 0.74 | ALDH1A1 (0.41) | KMT2AALDH1A1GAATDP1SMN1; SMN2 | |
| SCHEMBL8555792 | 0.74 | PDE2A (0.48) | PDE2AMEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL13730760 | 0.73 | ALDH1A1 (0.63) | MEN1KMT2ARXFP1ALDH1A1TDP1 | |
| SCHEMBL8559130 | 0.72 | POLB (0.43) | MEN1KMT2AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL13769278 | 0.72 | PDE2A (0.46) | PDE2A | |
| SCHEMBL8558973 | 0.69 | HPGD (0.44) | MEN1KMT2AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL22932762 | 0.69 | MEN1 (0.43) | PDE2AMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL7434502 | 0.69 | MEN1 (0.45) | MEN1KMT2AALDH1A1GAATDP1 | |
| SCHEMBL4102510 | 0.68 | PDE10A (0.43) | PDE2AMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591528-B1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE AND ANTI-INFLAMMATORY CONTAINING THE SAME | OTSUKA PHARMA CO LTD (JP) | 1998-12-23 | — | — | EP | claimed |
| US-5688949-A | CYCLOOXYGENASE INHIBITORS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1997-11-18 | — | — | US | claimed |
| EP-0591528-A1 | PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVE AND ANTI-INFLAMMATORY CONTAINING THE SAME | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1994-04-13 | — | — | EP | claimed |
| EP-0591528-B1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE AND ANTI-INFLAMMATORY CONTAINING THE SAME | OTSUKA PHARMA CO LTD (JP) | 1998-12-23 | — | — | EP | disclosed |
| US-5688949-A | CYCLOOXYGENASE INHIBITORS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1997-11-18 | — | — | US | disclosed |
| EP-0591528-A1 | PYRAZOLO 1,5-a]PYRIMIDINE DERIVATIVE AND ANTI-INFLAMMATORY CONTAINING THE SAME | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1994-04-13 | — | — | EP | disclosed |