Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 5/20 | 0.43 |
| ▸ | RXRB | P28702 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.40 |
| ▸ | CYP26B1 | Q9NR63 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | RARB | P10826 | 8/20 | 0.40 |
| ▸ | RARG | P13631 | 8/20 | 0.40 |
| ▸ | RARA | P10276 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557343 | 0.80 | CTSS (0.48) | RXRARXRBMAPTCYP26A1CYP26B1 | |
| SCHEMBL8556496 | 0.80 | RXRA (0.47) | RXRARXRBCYP26A1CYP26B1CYP3A4 | |
| SCHEMBL8556266 | 0.77 | RARG (0.45) | RXRARXRBCYP26A1CYP26B1CYP3A4 | |
| SCHEMBL8556008 | 0.74 | RXRA (0.48) | RXRARXRBMAPTCYP26A1CYP26B1 | |
| SCHEMBL8557284 | 0.74 | RXRA (0.46) | PSEN1PSEN2SPPL2AAPH1BNCSTN | |
| SCHEMBL8556007 | 0.73 | RARB (0.50) | RXRARXRBCYP26A1CYP26B1CYP3A4 | |
| SCHEMBL8106316 | 0.73 | CYP26A1 (0.44) | RXRARXRBCYP26A1CYP26B1CYP3A4 | |
| SCHEMBL8681352 | 0.71 | RXRA (0.44) | PSEN1PSEN2SPPL2AAPH1BNCSTN | |
| SCHEMBL8093046 | 0.70 | RARB (0.64) | RXRARXRBCYP26A1CYP26B1CYP3A4 | |
| SCHEMBL8103042 | 0.70 | RARB (0.47) | RXRARXRBMAPTCYP26A1CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0853619-A1 | DISUBSTITUTED PIPERIDINE DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 1998-07-22 | — | — | EP | claimed |
| WO-1997013769-A1 | DISUBSTITUTED PIPERIDINE DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 1997-04-17 | — | — | WO | claimed |
| US-5709867-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-01-20 | — | — | US | disclosed |