Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.47 |
| ▸ | RXRB | P28702 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.44 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.44 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.44 |
| ▸ | RARB | P10826 | 11/20 | 0.44 |
| ▸ | RARG | P13631 | 11/20 | 0.44 |
| ▸ | RARA | P10276 | 8/20 | 0.44 |
| ▸ | RXRG | P48443 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HNF4A | P41235 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556266 | 0.83 | RARG (0.45) | RXRARXRBCYP3A4CYP26A1CYP26B1 | |
| SCHEMBL8556008 | 0.81 | RXRA (0.48) | RXRARXRBCYP3A4CYP26A1CYP26B1 | |
| SCHEMBL8555851 | 0.80 | PSEN1 (0.44) | RXRARXRBCYP3A4CYP26A1CYP26B1 | |
| SCHEMBL8561925 | 0.79 | CTSS (0.50) | RXRARXRBCYP3A4CYP26A1CYP26B1 | |
| SCHEMBL8556007 | 0.75 | RARB (0.50) | RXRARXRBCYP3A4CYP26A1CYP26B1 | |
| SCHEMBL8093046 | 0.74 | RARB (0.64) | RXRARXRBCYP3A4CYP26A1CYP26B1 | |
| SCHEMBL8102765 | 0.73 | KMT2A (0.50) | RXRARXRBCYP3A4CYP26A1CYP26B1 | |
| SCHEMBL8102916 | 0.72 | RARB (0.51) | RXRARXRBCYP3A4CYP26A1CYP26B1 | |
| SCHEMBL8103042 | 0.71 | RARB (0.47) | RXRARXRBCYP3A4CYP26A1CYP26B1 | |
| SCHEMBL8839167 | 0.71 | RXRA (0.51) | RXRARXRBCYP3A4CYP26A1CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5709867-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-01-20 | — | — | US | disclosed |