Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 17/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556508 | 0.91 | P4HTM (0.51) | P4HTMALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL9120832 | 0.88 | MAPK1 (0.54) | P4HTMALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL9120660 | 0.84 | MAPK1 (0.55) | P4HTMALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL8458858 | 0.82 | HTT (0.57) | ALDH1A1KDM4ENPC1RAB9APOLB | |
| SCHEMBL8458561 | 0.76 | MEN1 (0.61) | ALDH1A1NPC1RAB9AMEN1LMNA | |
| SCHEMBL9895324 | 0.76 | P4HTM (1.00) | P4HTMALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL24892240 | 0.75 | P4HTM (0.75) | P4HTMALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL2407636 | 0.74 | P4HTM (0.54) | P4HTMMEN1KMT2A | |
| SCHEMBL8552419 | 0.74 | RARA (0.71) | P4HTMALDH1A1MEN1KMT2A | |
| SCHEMBL13816279 | 0.72 | LMNA (0.59) | ALDH1A1NPC1RAB9APOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5420145-A | Antileukemia | Shudo, Koichi (JP) | 1995-05-30 | — | — | US | claimed |
| EP-0619116-A2 | Use of synthetic retinoids for osteopathy | HOECHST JAPAN LIMITED (JP) | 1994-10-12 | — | — | EP | claimed |
| EP-0617020-A1 | Carboxylic acid derivatives having retinoic acid-like activity | Shudo, Koichi, Prof. Dr. (JP) | 1994-09-28 | — | — | EP | claimed |
| US-5767146-A | Anti-osteopathic composition | HOECHST JAPAN LIMITED (JP) | 1998-06-16 | — | — | US | disclosed |
| US-5716995-A | TREATING OR PREVENTING BONE DISEASES BY ADMINISTERING PHENOLIC, HETERO- OR NAPHTHYL- DERIVATIVES OF 1-HYDROXY-3-OXO-1-PROPENYL BENZOIC ACID TO PROMOTE OSTEOGENESIS | HOECHST JAPAN LIMITED (JP) | 1998-02-10 | — | — | US | disclosed |
| US-5703128-A | TREATING OSTEOPOROSIS, BONE FRACTURES | HOECHST JAPAN LIMITED (JP) | 1997-12-30 | — | — | US | disclosed |
| US-5525618-A | ENHANCING OSTEOGENESIS, PREVENTING OSTEOPOROSIS | HOECHST JAPAN LIMITED (JP) | 1996-06-11 | — | — | US | disclosed |
| US-5424313-A | Bibyclic heteroacrylpiperazine derivatives having psychotropic activity, and pharmaceutical compositions containing these derivatives | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1995-06-13 | — | — | US | disclosed |
| US-5420145-A | Antileukemia | Shudo, Koichi (JP) | 1995-05-30 | — | — | US | disclosed |
| EP-0619116-A2 | Use of synthetic retinoids for osteopathy | HOECHST JAPAN LIMITED (JP) | 1994-10-12 | — | — | EP | disclosed |
| EP-0617020-A1 | Carboxylic acid derivatives having retinoic acid-like activity | Shudo, Koichi, Prof. Dr. (JP) | 1994-09-28 | — | — | EP | disclosed |