Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4953933 | 0.84 | TP53 (0.48) | TDP1TP53NPC1CASP3SENP8 | |
| SCHEMBL8207446 | 0.84 | TP53 (0.48) | TDP1TP53NPC1CASP3SENP8 | |
| SCHEMBL7377625 | 0.82 | VNN1 (0.45) | TDP1TP53KDM4ELMNAHPGD | |
| SCHEMBL8097032 | 0.82 | TP53 (0.50) | TDP1TP53NPC1CASP3SENP8 | |
| SCHEMBL16494233 | 0.79 | TP53 (0.44) | TDP1TP53NPC1CASP3SENP8 | |
| SCHEMBL5966235 | 0.77 | CYP1A2 (0.46) | LMNACYP1A2MAOBSMN1; SMN2CYP11B1 | |
| SCHEMBL8202649 | 0.75 | CYP3A4 (0.48) | NPC1RAB9AKDM4ELMNAHPGD | |
| SCHEMBL1611151 | 0.73 | TP53 (0.58) | TDP1TP53NPC1CASP3SENP8 | |
| SCHEMBL8200491 | 0.73 | CYP11B2 (0.47) | NPC1RAB9AKDM4EKMT2ACYP1A2 | |
| SCHEMBL8667992 | 0.72 | RELA (0.43) | NPC1RAB9AKDM4ECHEK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832076-A1 | NOVEL ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |