SCHEMBL8555982

SCHEMBL8555982

O=C(O)c1nccn1C1Cc2cc(Br)ccc2C1=O

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
METAP1 P53582 2/20 0.38
SRD5A1 P18405 1/20 0.37
SRD5A2 P31213 1/20 0.37
PTAFR P25105 1/20 0.33
PARP10 Q53GL7 1/20 0.33
PARP11 Q9NR21 1/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
EDNRB P24530 1/20 0.32
EDNRA P25101 1/20 0.32
SDCBP O00560 1/20 0.30
SDC2 P34741 1/20 0.30
SLC11A2 P49281 1/20 0.30
TDP2 O95551 1/20 0.30
CYP19A1 P11511 1/20 0.30
SORT1 Q99523 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8552754 0.89 METAP1 (0.38) METAP1SRD5A1SRD5A2PTAFRPARP10
SCHEMBL7849300 0.86 DRD3 (0.38) PTAFR
SCHEMBL8558748 0.86 METAP1 (0.39) METAP1PTAFRPARP10PARP11KDM4E
SCHEMBL8557548 0.86 METAP1 (0.38) METAP1SRD5A1SRD5A2
SCHEMBL8881385 0.84 GABRG2 (0.41) METAP1KDM4EALDH1A1SMN1; SMN2TDP2
SCHEMBL8316780 0.83 CYP19A1 (0.45) METAP1PTAFRKDM4EALDH1A1CYP19A1
SCHEMBL8558771 0.83 KDM4E (0.40) METAP1KDM4ESMN1; SMN2CYP19A1
SCHEMBL8556767 0.79 ACHE (0.44) PTAFRPARP10
SCHEMBL7848070 0.79 HTR2A (0.38) SRD5A1SRD5A2PTAFRPARP10ALDH1A1
SCHEMBL8882795 0.79 METAP1 (0.43) METAP1SRD5A1PARP10PARP11SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0662971-B1 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM RHONE POULENC RORER SA (FR) 1998-05-13 EP disclosed
US-5677306-A ANTAGONIZING ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID RECEPTOR, USEFUL FOR TREATING ALL ISCHEMIAS RHONE-POULENC RORER S.A. (FR) 1997-10-14 US disclosed
EP-0662971-A1 DERIVATIVES OF 5H,10H-IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-4-ONE, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM Aventis Pharma S.A. (FR) 1995-07-19 EP disclosed
WO-1994007893-A1 DERIVATIVES OF 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM RHONE-POULENC RORER S.A. (FR) 1994-04-14 WO disclosed