Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.34 |
| ▸ | KDM4A | O75164 | 2/20 | 0.34 |
| ▸ | KMO | O15229 | 2/20 | 0.34 |
| ▸ | KIF11 | P52732 | 5/20 | 0.33 |
| ▸ | PTAFR | P25105 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7849300 | 0.91 | DRD3 (0.38) | ACHEKDM4CKDM4AKMOPTAFR | |
| SCHEMBL7848070 | 0.86 | HTR2A (0.38) | PTAFRPARP1PARP10GRM1GRM4 | |
| SCHEMBL8880818 | 0.84 | ACHE (0.41) | ACHE | |
| SCHEMBL8558771 | 0.83 | KDM4E (0.40) | ACHEPARP1 | |
| SCHEMBL8315983 | 0.80 | DRD3 (0.37) | ACHEPTAFRGRM1GRM4NOS3 | |
| SCHEMBL8555982 | 0.79 | METAP1 (0.38) | PTAFRPARP10 | |
| SCHEMBL8557548 | 0.79 | METAP1 (0.38) | — | |
| SCHEMBL8558748 | 0.79 | METAP1 (0.39) | ACHEPTAFRPARP10GRM1GRM4 | |
| SCHEMBL8555959 | 0.76 | KIF11 (0.34) | KDM4CKDM4AKIF11GRM4KDM5A | |
| SCHEMBL8316780 | 0.76 | CYP19A1 (0.45) | ACHEPTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662971-B1 | 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM | RHONE POULENC RORER SA (FR) | 1998-05-13 | — | — | EP | disclosed |
| EP-0662971-A1 | DERIVATIVES OF 5H,10H-IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-4-ONE, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM | Aventis Pharma S.A. (FR) | 1995-07-19 | — | — | EP | disclosed |
| WO-1994007893-A1 | DERIVATIVES OF 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1994-04-14 | — | — | WO | disclosed |