SCHEMBL8556056

SCHEMBL8556056

O=C1CNc2ccccc2S1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 7/20 0.46
MAPT P10636 6/20 0.46
MEN1 O00255 4/20 0.46
KMT2A Q03164 4/20 0.46
NOX1 Q9Y5S8 4/20 0.46
ALOX15 P16050 3/20 0.46
BCHE P06276 2/20 0.46
ACHE P22303 2/20 0.46
SNCA P37840 2/20 0.46
CYP1A2 P05177 1/20 0.46
POLB P06746 1/20 0.46
CYP3A4 P08684 1/20 0.46
ADORA3 P0DMS8 1/20 0.46
ALOX12 P18054 1/20 0.46
MAOA P21397 1/20 0.46
CNR1 P21554 1/20 0.46
PTGS1 P23219 1/20 0.46
SLC6A2 P23975 1/20 0.46
HTR2C P28335 1/20 0.46
PTGS2 P35354 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9635081 0.76 CA12 (0.52) GAAMAPTALOX15POLBTDP1
SCHEMBL4510651 0.75 GAA (0.52) GAAMAPTMEN1KMT2ANOX1
SCHEMBL15631689 0.73 NOX1 (0.39) GAAMAPTMEN1KMT2ANOX1
SCHEMBL7275482 0.73 MEN1 (0.46) GAAMAPTMEN1KMT2ATDP1
SCHEMBL9834304 0.72 GAA (0.40) GAAMAPTMEN1KMT2ANOX1
SCHEMBL7427944 0.72 ALDH1A1 (0.48) GAAMAPTMEN1KMT2ANOX1
SCHEMBL8853727 0.72 GAA (0.54) GAAMAPTMEN1KMT2ANOX1
SCHEMBL5739509 0.71 CYP2A6 (0.35) PTGS2TDP1ALDH1A1RAB9AKDM4E
SCHEMBL9628939 0.71 NPC1 (0.53) GAAMAPTMEN1KMT2ANOX1
SCHEMBL9850768 0.71 ALDH1A1 (0.47) GAAMAPTMEN1KMT2AALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111630167-B Antisense oligonucleotides for modulating T cell function 新加坡科技研究局 2024-08-09 CN disclosed
CN-118265791-A Spherical nucleic acids for cGAS-STING and STAT3 pathway modulation for immunotherapeutic treatment of cancer 西北大学 2024-06-28 CN disclosed
CN-117835967-A Compositions and methods for targeted delivery to cells 瑞科德治疗公司 2024-04-05 CN disclosed
CN-117751190-A Compositions and methods for modulating SOS gene expression 美国微哲默理有限责任公司 2024-03-22 CN disclosed
CN-117750948-A Compositions and methods for targeted systemic delivery to cells 瑞科德治疗公司 2024-03-22 CN disclosed
CN-117683769-A Nucleic acid oligomer and use thereof 瑞普鲁卡私人有限公司 2024-03-12 CN disclosed
CN-117597112-A Extracellular vesicles loaded with biomolecules 鉴识生物系统有限公司 2024-02-23 CN disclosed
CN-117157104-A Targeting multiple T cell types using spherical nucleic acid vaccine architecture 西北大学 2023-12-01 CN disclosed
CN-116940679-A Oligomeric compounds for dystrophin rescue in DMD patients by skipping of exon-51 SQY治疗公司 2023-10-24 CN disclosed
CN-116802193-A Engineered coronavirus spike (S) proteins and methods of use thereof 得克萨斯州大学系统董事会 2023-09-22 CN disclosed
CN-109796423-B Method for synthesizing 1, 3-thiazine-4-ketone under metal-free catalysis condition 温州大学 2022-11-11 CN disclosed
US-20220340890-A1 RNA-GUIDED NUCLEASES AND DNA BINDING PROTEINS INARI AGRICULTURE TECHNOLOGY, INC. 2022-10-27 US disclosed
CN-114929336-A Compounds and methods for modulating gene splicing 阿尔奈科学有限责任公司 2022-08-19 CN disclosed
CN-114207129-A Agents and methods for replication, transcription and translation in semi-synthetic organisms 斯克利普斯研究所 2022-03-18 CN disclosed
CN-114058617-A Conjugated antisense compounds and uses thereof IONIS制药公司 2022-02-18 CN disclosed
US-20190119726-A1 ERROR CORRECTION IN AMPLIFICATION OF SAMPLES CELLULAR RESEARCH, INC. 2019-04-25 US disclosed
WO-2012083363-A1 A METHOD OF TREATMENT MURDOCH CHILDRENS RESEARCH INSTITUTE (AU) 2012-06-28 WO disclosed
EP-0529452-B1 1,7-Condensed 3-(piperazinoalkyl)indol derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them SOLVAY PHARM GMBH (DE) 1998-11-11 EP disclosed
US-5324725-A Antiinflammatory agent, antiallergen KALI-CHEMIE PHARMA GMBH (DE) 1994-06-28 US disclosed
EP-0529452-A2 1,7-Condensed 2-(piperazinoalkyl)indol derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them Kali-Chemie Pharma GmbH (DE) 1993-03-03 EP disclosed