Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 2/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7146808 | 0.74 | ALOX15 (0.51) | ALDH1A1ALOX15MAPK10HSD17B10SMN1; SMN2 | |
| SCHEMBL8556056 | 0.71 | GAA (0.46) | ALDH1A1ALOX15MAPK10HSD17B10SMN1; SMN2 | |
| SCHEMBL12210337 | 0.68 | TDP1 (0.45) | ALDH1A1SMN1; SMN2GAAKDM4ECYP1A2 | |
| SCHEMBL14990432 | 0.68 | — | — | |
| SCHEMBL6080268 | 0.66 | ALDH1A1 (0.46) | ALDH1A1ALOX15MAPK10HSD17B10SMN1; SMN2 | |
| SCHEMBL5757843 | 0.65 | ALDH1A1 (0.50) | ALDH1A1ALOX15MAPK10HSD17B10SMN1; SMN2 | |
| SCHEMBL9178250 | 0.65 | ALDH1A1 (1.00) | ALDH1A1ALOX15MAPK10HSD17B10SMN1; SMN2 | |
| SCHEMBL2044013 | 0.65 | — | — | |
| SCHEMBL6686095 | 0.64 | GSK3B (0.38) | ALDH1A1ALOX15MAPK10HSD17B10SMN1; SMN2 | |
| SCHEMBL626994 | 0.64 | GSK3B (0.49) | ALDH1A1ALOX15MAPK10HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416740-A2 | Novel compounds with renin-inhibiting activity | Beecham Group p.l.c. (GB) | 1991-03-13 | — | — | EP | disclosed |