Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556168 | 0.84 | DRD2 (0.44) | DRD2DRD3KCNH2NOTUMOPRL1 | |
| SCHEMBL8093681 | 0.84 | NOTUM (0.45) | DRD2DRD3KCNH2NOTUMOPRL1 | |
| SCHEMBL8606800 | 0.81 | CA12 (0.45) | DRD2DRD3KCNH2 | |
| SCHEMBL6507723 | 0.81 | DRD2 (0.42) | DRD2DRD3KCNH2NOTUMOPRL1 | |
| SCHEMBL8788951 | 0.80 | NOTUM (0.42) | DRD2DRD3KCNH2NOTUMHCRTR1 | |
| SCHEMBL8885582 | 0.78 | DRD2 (0.42) | DRD2DRD3KCNH2NOTUMOPRL1 | |
| SCHEMBL27494128 | 0.78 | DRD2 (0.40) | DRD2DRD3KCNH2NOTUMOPRL1 | |
| SCHEMBL8787181 | 0.78 | FFAR4 (0.49) | DRD2DRD3KCNH2NOTUMOPRL1 | |
| SCHEMBL8786870 | 0.78 | NOTUM (0.43) | DRD2DRD3KCNH2NOTUMOPRL1 | |
| SCHEMBL8597721 | 0.77 | OPRL1 (0.42) | DRD2DRD3KCNH2NOTUMOPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1203599-A | Substitued pyrrolidinone, thiazolidinone or oxazolidinone as herbicides | ZENECA LTD (GB) | 1998-12-30 | — | — | CN | disclosed |
| EP-0863894-A1 | SUBSTITUTED PYRROLIDINONE, THIAZOLIDINONE OR OXAZOLIDINONE AS HERBICIDES | ZENECA LIMITED (GB) | 1998-09-16 | — | — | EP | disclosed |
| US-5705456-A | AZETIDIN-2-ONES | ZENECA LIMITED (GB) | 1998-01-06 | — | — | US | disclosed |
| WO-1997020838-A1 | SUBSTITUTED PYRROLIDINONE, THIAZOLIDINONE OR OXAZOLIDINONE AS HERBICIDES | ZENECA LIMITED (GB) | 1997-06-12 | — | — | WO | disclosed |