Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.51 |
| ▸ | APAF1 | O14727 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554663 | 0.88 | BCHE (0.53) | HDAC8HDAC1HDAC6L3MBTL1MAPT | |
| SCHEMBL10975012 | 0.88 | MAPT (0.52) | L3MBTL1APAF1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL8557712 | 0.84 | HDAC1 (0.54) | HDAC8HDAC1HDAC6L3MBTL1SMN1; SMN2 | |
| SCHEMBL29351902 | 0.77 | HDAC8 (0.59) | HDAC8HDAC1HDAC6SMN1; SMN2MAPT | |
| SCHEMBL5608865 | 0.77 | HDAC8 (0.59) | HDAC8HDAC1HDAC6SMN1; SMN2MAPT | |
| SCHEMBL25485 | 0.76 | POLB (0.64) | L3MBTL1SMN1; SMN2MAPTALDH1A1HPGD | |
| SCHEMBL25683657 | 0.75 | NQO1 (0.48) | MAPTALDH1A1HPGDP2RX7MEN1 | |
| SCHEMBL15854548 | 0.74 | HDAC8 (0.60) | HDAC8HDAC1HDAC6SMN1; SMN2MAPT | |
| SCHEMBL11445680 | 0.74 | HDAC8 (0.56) | HDAC8HDAC1HDAC6SMN1; SMN2MAPT | |
| SCHEMBL12871405 | 0.74 | HDAC8 (0.56) | HDAC8HDAC1HDAC6L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653426-B1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA CO (JP) | 1998-07-22 | — | — | EP | disclosed |
| US-5510366-A | INOTROPIC, ANTIARRHYMTHMIA AGENTS, VASODILATORS | KOWA CO., LTD. (JP) | 1996-04-23 | — | — | US | disclosed |
| EP-0653426-A1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA COMPANY, LTD. (JP) | 1995-05-17 | — | — | EP | disclosed |