SCHEMBL25485

SCHEMBL25485

CCOc1ccc(NCc2ccccc2)cc1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.64
KMT2A Q03164 4/20 0.62
MAPT P10636 3/20 0.62
MEN1 O00255 3/20 0.62
GAA P10253 2/20 0.62
TP53 P04637 1/20 0.62
BLM P54132 1/20 0.62
ATM Q13315 1/20 0.62
L3MBTL1 Q9Y468 3/20 0.60
KDM4E B2RXH2 1/20 0.60
ALDH1A1 P00352 1/20 0.60
APP P05067 1/20 0.60
ALOX15 P16050 1/20 0.60
ALOX12 P18054 1/20 0.60
MAPK1 P28482 1/20 0.60
SNCA P37840 1/20 0.60
TDP1 Q9NUW8 1/20 0.60
HTT P42858 1/20 0.59
NPC1 O15118 2/20 0.56
RAB9A P51151 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17371150 0.93 NPC1 (0.61) POLBKMT2AMAPTMEN1GAA
SCHEMBL3272089 0.91 MAPT (0.69) POLBKMT2AMAPTMEN1GAA
SCHEMBL9594129 0.85 DRD4 (0.53) POLBKMT2AMAPTMEN1GAA
SCHEMBL11838896 0.84 MAPT (0.84) KMT2AMAPTMEN1GAATP53
SCHEMBL28191314 0.83 MAPT (0.71) POLBKMT2AMAPTMEN1GAA
SCHEMBL855997 0.82 CACNA1B (0.58) KMT2AMAPTMEN1GAATP53
N-Benzyl-4-Methoxyaniline SCHEMBL1757104 0.81 HIF1A (0.69) KMT2AMAPTMEN1GAATP53
SCHEMBL23873637 0.81 ALDH1A1 (0.72) POLBKMT2AMAPTMEN1GAA
SCHEMBL11215247 0.81 CACNA1B (0.60) KMT2AMAPTMEN1GAAL3MBTL1
SCHEMBL1924100 0.80 HTT (0.78) KMT2AMAPTMEN1GAATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0606858-B1 Liquid crystal compositions and liquid crystal display devices CHISSO CORP (JP) 2000-04-26 EP claimed
EP-4721766-A1 COMBINATION OF (ANTI-HER3 ANTIBODY)-DRUG CONJUGATE AND RASG12C INHIBITOR Daiichi Sankyo Company, Limited (JP) 2026-04-08 EP disclosed
WO-2022004388-A1 5'-MODIFIED NUCLEOSIDE AND NUCLEOTIDE USING SAME 国立大学法人大阪大学 2022-01-06 WO disclosed
WO-2021256297-A1 BRIDGED NUCLEOSIDE AND NUCLEOTIDE リードファーマ株式会社 2021-12-23 WO disclosed
US-9657050-B2 ENA nucleic acid pharmaceuticals capable of modifying splicing of mRNA precursors Masafumi, Matsuo (JP) 2017-05-23 US disclosed
EP-2530154-B1 ENA nucleic acid drugs modifying splicing in mRNA precursor MATSUO MASAFUMI (JP) 2016-03-16 EP disclosed
EP-2530155-B1 ENA nucleic acid drugs modifying splicing in mRNA precursor MATSUO MASAFUMI (JP) 2016-03-16 EP disclosed
EP-2530153-B1 ENA nucleic acid drugs modifying splicing in mRNA precursor MATSUO MASAFUMI (JP) 2016-03-16 EP disclosed
EP-2386636-B1 ENA NUCLEIC ACID DRUGS MODIFYING SPLICING IN MRNA PRECURSOR MATSUO MASAFUMI (JP) 2016-01-27 EP disclosed
US-9243026-B2 ENA nucleic acid pharmaceuticals capable of modifying splicing of mRNA precursors DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-01-26 US disclosed
US-20030144316-A1 Remedies TAKARA BIO INC. (JP) 2003-07-31 US disclosed
US-20030004208-A1 Process for producing stereoisomer of pyrrolidine derivative EISAI CO., LTD. (JP) 2003-01-02 US disclosed
EP-1256573-A1 Process for producing stereoisomer of pyrrolidine derivative Eisai Co., Ltd. (JP) 2002-11-13 EP disclosed
EP-1254658-A1 REMEDIES TAKARA BIO INC. (JP) 2002-11-06 EP disclosed
EP-1231210-A2 Azole antifungal agents, processes for the preparation thereof, and intermediates Eisai Co., Ltd. (JP) 2002-08-14 EP disclosed
EP-1099440-A1 THERAPEUTIC AGENTS Takara Shuzo Co, Ltd. (JP) 2001-05-16 EP disclosed
US-5792781-A EFFECTIVE AGAINST DERMATOMYCOSIS/VISCEROMYCOSIS CAUSED BY FUNGI, I.E., CANDIDA ALBICANS EISAI CO., LTD. (JP) 1998-08-11 US disclosed
US-5789429-A FUNGICIDE EISAI CO., LTD. (JP) 1998-08-04 US disclosed
US-5648372-A TRIAZOLES EISAI CO., LTD. (JP) 1997-07-15 US disclosed
EP-0667346-A2 Azole antifungal agents, process for the preparation there of and intermediates Eisai Co., Ltd. (JP) 1995-08-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030004208-A1 Process for producing stereoisomer of pyrrolidine derivative DHPS, SQLE, FDFT1 POLB 929/4885KMT2A 1523/4885MAPT 3664/4885
US-20030144316-A1 Remedies NGF, BDNF, NTRK2 POLB 4436/4885KMT2A 3404/4885MAPT 1407/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.