Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | TACR3 | P29371 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ACP1 | P24666 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11037476 | 0.87 | GAA (0.59) | TACR3RAB9AL3MBTL1MAPTNPC1 | |
| SCHEMBL17714698 | 0.84 | ADRA2C (0.58) | HDAC1RAB9AL3MBTL1MAPTNPC1 | |
| SCHEMBL8556370 | 0.84 | HDAC8 (0.51) | HDAC1HDAC8HDAC6L3MBTL1MAPT | |
| SCHEMBL8554663 | 0.84 | BCHE (0.53) | HDAC1HDAC8HDAC6RAB9AL3MBTL1 | |
| SCHEMBL30691740 | 0.84 | HDAC8 (0.60) | HDAC1HDAC8HDAC6TACR3L3MBTL1 | |
| SCHEMBL17714700 | 0.83 | RAB9A (0.57) | RAB9ALMNATP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL6814420 | 0.83 | NCF1 (0.54) | HDAC1TACR3RAB9AL3MBTL1NPC1 | |
| SCHEMBL5511518 | 0.83 | TDP1 (0.57) | HDAC1HDAC8HDAC6TACR3RAB9A | |
| SCHEMBL6689330 | 0.83 | LMNA (0.55) | HDAC1HDAC8HDAC6TACR3RAB9A | |
| SCHEMBL10787691 | 0.81 | RAB9A (0.55) | TACR3RAB9AMAPTNPC1ACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653426-B1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA CO (JP) | 1998-07-22 | — | — | EP | disclosed |
| US-5510366-A | INOTROPIC, ANTIARRHYMTHMIA AGENTS, VASODILATORS | KOWA CO., LTD. (JP) | 1996-04-23 | — | — | US | disclosed |
| EP-0653426-A1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA COMPANY, LTD. (JP) | 1995-05-17 | — | — | EP | disclosed |