SCHEMBL8556413

CC(C)(C)OC(=O)C(N1C(=O)[C@@H](NC(=O)COc2ccccc2)[C@H]1SCC(=O)[C@H]1COC(=O)C1)=P(c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	LMNA	P02545	2/20	0.35

▸	POLB	P06746	1/20	0.35

▸	TP53	P04637	1/20	0.34

▸	ALDH1A1	P00352	1/20	0.34

▸	CYP1A2	P05177	1/20	0.34

▸	CYP2D6	P10635	1/20	0.34

▸	CYP2C19	P33261	1/20	0.34

▸	CTDSP1	Q9GZU7	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL8556411	1.00	LMNA (0.35)	LMNAPOLBTP53ALDH1A1CYP1A2
SCHEMBL8557354	0.86	LMNA (0.33)	LMNAPOLBTP53ALDH1A1CYP1A2
SCHEMBL11255786	0.81	ALDH1A1 (0.39)	LMNAPOLBTP53ALDH1A1CYP1A2
SCHEMBL11254587	0.80	ALDH1A1 (0.40)	LMNATP53ALDH1A1CYP1A2CYP2D6
SCHEMBL11261138	0.79	ALDH1A1 (0.37)	LMNATP53ALDH1A1CYP1A2CYP2D6
SCHEMBL9487619	0.77	POLB (0.39)	LMNAPOLBTP53ALDH1A1CYP1A2
SCHEMBL9487615	0.77	POLB (0.39)	LMNAPOLBTP53ALDH1A1CYP1A2
SCHEMBL8554812	0.77	POLB (0.39)	LMNAPOLBTP53CYP1A2
SCHEMBL8554815	0.77	POLB (0.39)	LMNAPOLBTP53CYP1A2
SCHEMBL11541505	0.77	CTDSP1 (0.42)	POLBTP53ALDH1A1CYP2C19CTDSP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0395219-B1	Cephalosporins and their homologues, process for their preparation and pharmaceutical compositions	PFIZER (US)	1998-09-30	—	—	EP	disclosed
US-5246926-A	Bactericides	BEECHAM GROUP P.L.C. (GB)	1993-09-21	—	—	US	disclosed