SCHEMBL8556526

SCHEMBL8556526

O=S(=O)(Nc1oc(Cc2ccccc2)nc1-c1cccc(F)c1)c1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.46
ALDH1A1 P00352 3/20 0.46
PTPN1 P18031 5/20 0.44
PTPN5 P54829 5/20 0.44
SLC40A1 Q9NP59 1/20 0.41
PDE4A P27815 1/20 0.41
PDE4B Q07343 1/20 0.41
PDE4C Q08493 1/20 0.41
PDE4D Q08499 1/20 0.41
MALT1 Q9UDY8 1/20 0.41
PTPN2 P17706 4/20 0.41
HSPD1 P10809 2/20 0.41
HSPE1 P61604 2/20 0.41
MAP2K7 O14733 1/20 0.41
MAP2K4 P45985 1/20 0.41
LMNA P02545 1/20 0.40
KAT6A Q92794 1/20 0.40
LIMK2 P53671 3/20 0.39
EDNRB P24530 1/20 0.38
EDNRA P25101 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8555603 0.91 MAPT (0.48) MAPTALDH1A1PTPN1PTPN5SLC40A1
SCHEMBL8556764 0.89 MAPT (0.54) MAPTALDH1A1PTPN1PTPN5SLC40A1
SCHEMBL8557761 0.88 MAPT (0.49) MAPTALDH1A1PTPN1PTPN5SLC40A1
SCHEMBL8555498 0.87 ALDH1A1 (0.49) MAPTALDH1A1PTPN1PTPN5SLC40A1
SCHEMBL8557990 0.87 MAPT (0.46) MAPTALDH1A1PTPN1PTPN5SLC40A1
SCHEMBL8555138 0.87 PGR (0.50) MAPTALDH1A1PTPN1MALT1PTPN2
SCHEMBL8557213 0.86 MAPT (0.47) MAPTALDH1A1SLC40A1MALT1LMNA
SCHEMBL8556290 0.84 MAPT (0.51) MAPTALDH1A1PTPN1PTPN5SLC40A1
SCHEMBL8556990 0.84 MAPT (0.47) MAPTALDH1A1SLC40A1MALT1LMNA
SCHEMBL8559666 0.84 ALDH1A1 (0.50) MAPTALDH1A1SLC40A1PDE4APDE4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5719163-A ARTHRITIS G.D. SEARLE & CO. (US) 1998-02-17 US disclosed