Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LIMK2 | P53671 | 3/20 | 0.40 |
| ▸ | EDNRB | P24530 | 4/20 | 0.38 |
| ▸ | EDNRA | P25101 | 4/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556990 | 0.92 | MAPT (0.47) | MAPTALDH1A1MALT1TP53LMNA | |
| SCHEMBL8557990 | 0.91 | MAPT (0.46) | MAPTALDH1A1LMNASLC40A1TSHR | |
| SCHEMBL8561399 | 0.91 | ALDH1A1 (0.49) | MAPTALDH1A1LMNASLC40A1TSHR | |
| SCHEMBL8559259 | 0.88 | MAPT (0.47) | MAPTALDH1A1TP53LMNASLC40A1 | |
| SCHEMBL8561410 | 0.87 | PTGS2 (0.47) | MAPTALDH1A1TP53LMNASLC40A1 | |
| SCHEMBL8556526 | 0.86 | MAPT (0.46) | MAPTALDH1A1MALT1LMNASLC40A1 | |
| SCHEMBL9025385 | 0.86 | PTGS1 (0.43) | MAPTALDH1A1LMNASLC40A1 | |
| SCHEMBL8555603 | 0.86 | MAPT (0.48) | MAPTALDH1A1LMNASLC40A1TSHR | |
| SCHEMBL8558062 | 0.86 | ALDH1A1 (0.47) | MAPTALDH1A1LMNASLC40A1TSHR | |
| SCHEMBL9025734 | 0.85 | ALDH1A1 (0.44) | MAPTALDH1A1TP53LMNASLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |