SCHEMBL855653

SCHEMBL855653

O=C1OC(=O)c2c1cc(F)c(F)c2F

nearest known ligand 0.37

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
TYMS P04818 1/20 0.31
ALOX5 P09917 1/20 0.31
TSHR P16473 2/20 0.31
ALDH1A1 P00352 2/20 0.31
NOTUM Q6P988 1/20 0.30
NPC1 O15118 1/20 0.30
LMNA P02545 1/20 0.30
OPRD1 P41143 1/20 0.30
OPRK1 P41145 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30523205 1.00 ALOX15 (0.37) ALOX15TDP1TYMSALOX5TSHR
SCHEMBL28075771 0.82 TSHR (0.41) ALOX15TDP1TSHR
SCHEMBL4924942 0.82 ALDH1A1 (0.41) ALOX15TDP1TYMSTSHRALDH1A1
SCHEMBL28075773 0.82 TSHR (0.41) ALOX15TDP1TSHR
SCHEMBL27801935 0.82 ALDH1A1 (0.41) ALOX15TDP1TYMSTSHRALDH1A1
SCHEMBL15064639 0.81 ALOX15 (0.30) ALOX15TDP1
SCHEMBL4924952 0.79 ALDH1A1 (0.38) ALOX15TDP1TYMSTSHRALDH1A1
SCHEMBL127839 0.78 ALOX15 (0.33) ALOX15TDP1TYMSALDH1A1NPC1
SCHEMBL652925 0.76 ALOX15 (0.48) ALOX15TDP1TYMSALDH1A1NPC1
SCHEMBL29441718 0.76 ALOX15 (0.48) ALOX15TDP1TYMSALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120283089-A1 ZIEGLER-NATTA CATALYST FOR OLEFIN POLYMERIZATION HYOSUNG CORPORATION (KR) 2012-11-08 US claimed
EP-2520594-A2 ZIEGLER-NATTA CATALYST FOR OLEFIN POLYMERIZATION Hyosung Corporation (KR) 2012-11-07 EP claimed
CN-116632353-B Lithium ion battery electrolyte capable of inhibiting formation and growth of lithium dendrite and lithium ion battery 江苏兴杰固邦能源科技有限公司 2023-10-13 CN disclosed
CN-116632353-A Lithium ion battery electrolyte capable of inhibiting formation and growth of lithium dendrite and lithium ion battery 江苏兴杰固邦能源科技有限公司 2023-08-22 CN disclosed
EP-2433933-B1 PRODUCTION METHOD OF TRI- OR TETRAHALOGEN-SUBSTITUTED PHTHALIDE SUMITOMO CHEMICAL CO (JP) 2019-05-08 EP disclosed
US-8652986-B2 Ziegler-Natta catalyst for olefin polymerization HYOSUNG CORPORATION (KR) 2014-02-18 US disclosed
US-8604221-B2 Production method of halogen-substituted phthalide SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-12-10 US disclosed
US-20120283089-A1 ZIEGLER-NATTA CATALYST FOR OLEFIN POLYMERIZATION HYOSUNG CORPORATION (KR) 2012-11-08 US disclosed
EP-2520594-A2 ZIEGLER-NATTA CATALYST FOR OLEFIN POLYMERIZATION Hyosung Corporation (KR) 2012-11-07 EP disclosed
US-20120142946-A1 PRODUCTION METHOD OF HALOGEN-SUBSTITUTED PHTHALIDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-06-07 US disclosed
EP-2433933-A1 PRODUCTION METHOD OF HALOGEN-SUBSTITUTED PHTHALIDE Sumitomo Chemical Company, Limited (JP) 2012-03-28 EP disclosed
US-7348439-B2 2-aryl-3-(aminoaryl)-3-(hydroxyaryl)phthalimidine compounds and methods for making them GENERAL ELECTRIC COMPANY (US) 2008-03-25 US disclosed
US-20070197761-A1 2-ARYL-3-(AMINOARYL)-3-(HYDROXYARYL)PHTHALIMIDINE COMPOUNDS AND METHODS FOR MAKING THEM GENERAL ELECTRIC COMPANY (US) 2007-08-23 US disclosed
WO-2007064630-A1 2-ARYL-3-(AMINOARYL)-3-(HYDROXYARYL)PHTHALIMIDINE COMPOUNDS AND METHODS FOR MAKING THEM GENERAL ELECTRIC COMPANY (US) 2007-06-07 WO disclosed
US-20070123714-A1 2-ARYL-3-(AMINOARYL)-3-(HYDROXYARYL)PHTHALIMIDINE COMPOUNDS AND METHODS FOR MAKING THEM SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2007-05-31 US disclosed
WO-2007023998-A1 HALOGENATED POLYAMIDE ACID COMPOSITION AND ITS APPLICATIONS NIPPON SHOKUBAI CO., LTD. (JP) 2007-03-01 WO disclosed
US-20030157412-A1 Electrolyte and rechargeable lithium battery SAMSUNG SDI CO., LTD. (KR) 2003-08-21 US disclosed
US-4956265-A POLYUNSATURATED WITH ESTER AND CARBOXY GROUPS; PROTECTIVE COATINGS, GRAPHIC ARTS, PHOTORESTS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1990-09-11 US disclosed
US-4914165-A PHOTOCROSSLINKABLE POLYEPOXIDE POLYESTERS USING POLY (ETHYLENICALLY-UNSATURATED)ALKANOLS AND DICARBOXYLIC ACIDS; PROTECTIVE COATINGS; GRAPHIC ARTS; WEAR RESISTANCE; ADHESION MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1990-04-03 US disclosed
EP-0329298-A2 Radiation crosslinkable compositions MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1989-08-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070197761-A1 2-ARYL-3-(AMINOARYL)-3-(HYDROXYARYL)PHTHALIMIDINE COMPOUNDS AND METHODS FOR MAKING THEM AHR, ARNT, AR ALOX15 740/4885TDP1 1510/4885TYMS 2689/4885
US-20070123714-A1 2-ARYL-3-(AMINOARYL)-3-(HYDROXYARYL)PHTHALIMIDINE COMPOUNDS AND METHODS FOR MAKING THEM AHR, ARNT, AR ALOX15 740/4885TDP1 1510/4885TYMS 2689/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.