Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555167 | 0.85 | ROCK2 (0.63) | ROCK2SMN1; SMN2LMNAMAPK1ALDH1A1 | |
| SCHEMBL7707825 | 0.79 | ROCK2 (0.57) | ROCK2SMN1; SMN2LMNAMAPK1ALDH1A1 | |
| SCHEMBL8555308 | 0.79 | ROCK2 (0.62) | ROCK2SMN1; SMN2LMNAMAPK1ALDH1A1 | |
| SCHEMBL8555953 | 0.78 | ROCK2 (0.56) | ROCK2SMN1; SMN2LMNAMAPK1ALDH1A1 | |
| SCHEMBL8556812 | 0.77 | ROCK2 (0.60) | ROCK2SMN1; SMN2LMNAMAPK1ALDH1A1 | |
| SCHEMBL16377347 | 0.77 | ROCK2 (1.00) | ROCK2SMN1; SMN2MAPK1CASP6MAPK3 | |
| SCHEMBL17783613 | 0.76 | ROCK2 (1.00) | ROCK2SMN1; SMN2MAPK1CASP6MAPK3 | |
| SCHEMBL8554376 | 0.74 | ROCK2 (0.56) | ROCK2SMN1; SMN2LMNAMAPK1CASP6 | |
| SCHEMBL7701986 | 0.74 | ROCK2 (0.54) | ROCK2SMN1; SMN2LMNAMAPK1ALDH1A1 | |
| SCHEMBL18073895 | 0.74 | ROCK2 (0.56) | ROCK2SMN1; SMN2LMNAMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |