Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 3/20 | 0.58 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.58 |
| ▸ | OXTR | P30559 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556989 | 0.90 | AVPR1A (0.72) | AVPR2AVPR1AOXTR | |
| SCHEMBL8557460 | 0.86 | AVPR1A (0.64) | AVPR2AVPR1AOXTR | |
| SCHEMBL8559975 | 0.83 | AVPR2 (0.58) | AVPR2AVPR1AOXTRNAMPTNPC1 | |
| SCHEMBL8557382 | 0.81 | AVPR2 (0.50) | AVPR2AVPR1AOXTRNAMPTNPC1 | |
| SCHEMBL8558930 | 0.81 | AVPR2 (0.60) | AVPR2AVPR1AOXTRNPC1HPGD | |
| SCHEMBL8558454 | 0.80 | GRM1 (0.57) | AVPR2AVPR1AOXTR | |
| SCHEMBL8313980 | 0.80 | AVPR1A (0.52) | AVPR2AVPR1AOXTR | |
| SCHEMBL8562680 | 0.79 | ALDH1A1 (0.59) | AVPR2AVPR1AOXTRNAMPTHPGD | |
| SCHEMBL8559258 | 0.79 | AVPR2 (0.58) | AVPR2AVPR1AOXTR | |
| SCHEMBL8562670 | 0.79 | AVPR1A (0.60) | AVPR2AVPR1AOXTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |