Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | GSK3B | P49841 | 4/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | CETP | P11597 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557169 | 0.82 | HDAC1 (0.44) | HDAC3HDAC1HDAC2ALDH1A1GAA | |
| SCHEMBL9257413 | 0.75 | BRS3 (0.52) | HDAC3HDAC1HDAC2ALDH1A1MEN1 | |
| SCHEMBL30785575 | 0.75 | GAA (0.55) | HDAC3HDAC1HDAC2GAAKMT2A | |
| SCHEMBL16568954 | 0.74 | KMT2A (0.54) | HDAC3HDAC1HDAC2ALDH1A1GAA | |
| SCHEMBL20160888 | 0.74 | GSK3B (0.60) | HDAC3HDAC1HDAC2MEN1GAA | |
| Hydrochloric Acid SCHEMBL18208874 | 0.73 | GSK3B (0.59) | HDAC3HDAC1HDAC2MEN1GAA | |
| SCHEMBL29856319 | 0.72 | MAPT (0.62) | HDAC3HDAC1HDAC2ALDH1A1GAA | |
| SCHEMBL16703189 | 0.70 | GSK3B (0.53) | HDAC3HDAC1HDAC2MAPTGSK3B | |
| SCHEMBL14782130 | 0.69 | HDAC3 (0.53) | HDAC3HDAC1HDAC2GSK3B | |
| SCHEMBL29856133 | 0.69 | GSK3B (0.68) | MAPTGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |