SCHEMBL8557055

SCHEMBL8557055

O=C(O)CCc1ccc(C2CNC(=O)N2c2ccc3c(c2)CCNC3)cc1

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 2/20 0.38
ITGA2B P08514 2/20 0.38
QPCT Q16769 7/20 0.37
HTR6 P50406 4/20 0.37
RXRA P19793 1/20 0.35
RXRB P28702 1/20 0.35
RXRG P48443 1/20 0.35
QPCTL Q9NXS2 1/20 0.35
PLAU P00749 1/20 0.34
PARP1 P09874 1/20 0.34
PARP2 Q9UGN5 1/20 0.34
PARP3 Q9Y6F1 1/20 0.34
PPARD Q03181 1/20 0.34
PPARA Q07869 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8560495 0.94 HTR6 (0.43) ITGB3ITGA2BQPCTHTR6RXRA
SCHEMBL8562406 0.94 HTR6 (0.39) ITGB3ITGA2BQPCTHTR6RXRA
Hydrochloric Acid SCHEMBL8564105 0.87 TBXAS1 (0.38) QPCTHTR6RXRARXRBRXRG
SCHEMBL8559860 0.85 PARP1 (0.39) ITGB3ITGA2BQPCTRXRARXRB
Hydrochloric Acid SCHEMBL8563477 0.84 PARP1 (0.38) ITGB3ITGA2BQPCTRXRARXRB
Hydrochloric Acid SCHEMBL8566893 0.84 HTR6 (0.38) ITGB3ITGA2BHTR6RXRARXRB
SCHEMBL8564818 0.83 ESR1 (0.39) QPCTQPCTLPPARDPPARA
Hydrochloric Acid SCHEMBL8564483 0.83 HTR6 (0.40) QPCTHTR6RXRARXRBRXRG
Hydrochloric Acid SCHEMBL8559313 0.83 HTR6 (0.41) QPCTHTR6PARP1
SCHEMBL8559323 0.83 PARP1 (0.37) ITGB3ITGA2BQPCTRXRARXRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5827849-A HAVING INHIBITORY EFFECT ON INFLAMMATION AND BONE DEGRADATION, ANTITHROMBOTIC, ANTIAGGREGATORY AND TUMOR- OR METASTASIS-INHIBITING EFFECT KARL THOMAE GMBH (DE) 1998-10-27 US disclosed