Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8558307 | 0.99 | RAB9A (0.60) | NPC1RAB9ALMNAHPGDSIGMAR1 | |
| Bicarbonate SCHEMBL8557197 | 0.99 | RAB9A (0.60) | NPC1RAB9ALMNAHPGDSIGMAR1 | |
| Bicarbonate SCHEMBL8554569 | 0.90 | GAA (0.50) | NPC1RAB9ALMNASIGMAR1KMT2A | |
| Bicarbonate SCHEMBL8555157 | 0.88 | NPC1 (0.45) | NPC1RAB9ALMNAHPGDSIGMAR1 | |
| Bicarbonate SCHEMBL8559853 | 0.87 | SIGMAR1 (0.47) | NPC1RAB9ALMNAHPGDSIGMAR1 | |
| Bicarbonate SCHEMBL8555199 | 0.87 | SIGMAR1 (0.47) | NPC1RAB9ALMNAHPGDSIGMAR1 | |
| Bicarbonate SCHEMBL8557364 | 0.86 | SIGMAR1 (0.47) | NPC1RAB9ALMNAHPGDSIGMAR1 | |
| Bicarbonate SCHEMBL8556769 | 0.86 | SIGMAR1 (0.47) | NPC1RAB9ALMNAHPGDSIGMAR1 | |
| Bicarbonate SCHEMBL8556440 | 0.85 | TAS1R3 (0.57) | LMNAHPGD | |
| SCHEMBL9236845 | 0.84 | SIGMAR1 (0.46) | NPC1RAB9ALMNAHPGDSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0668267-B1 | Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AG (DE) | 1998-04-08 | — | — | EP | disclosed |
| EP-0668267-A1 | Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AG (DE) | 1995-08-23 | — | — | EP | disclosed |