Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 6/20 | 0.49 |
| ▸ | DRD2 | P14416 | 6/20 | 0.49 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468004 | 0.89 | ADRA2A (0.52) | ADRA2AADRA2BADRA2CHTR1ADRD2 | |
| SCHEMBL7475056 | 0.86 | HTR1A (0.54) | ADRA2AADRA2BADRA2CHTR1ADRD2 | |
| SCHEMBL7470011 | 0.86 | ADRA2A (0.48) | ADRA2AADRA2BADRA2CHTR1ADRD2 | |
| SCHEMBL7467112 | 0.86 | HTR1A (0.51) | HTR1ADRD2HTR2AHTR2CHTR2B | |
| SCHEMBL7467130 | 0.86 | HTR1A (0.51) | HTR1ADRD2HTR2AHTR2CHTR2B | |
| SCHEMBL7460328 | 0.86 | HTR1A (0.52) | ADRA2AADRA2BADRA2CHTR1ADRD2 | |
| SCHEMBL7475366 | 0.86 | HTR1A (0.54) | ADRA2AADRA2BADRA2CHTR1ADRD2 | |
| SCHEMBL7467649 | 0.85 | HTR1A (0.48) | ADRA2AADRA2BADRA2CHTR1ADRD2 | |
| SCHEMBL7469846 | 0.85 | HTR1A (0.48) | ADRA2AADRA2BADRA2CHTR1ADRD2 | |
| SCHEMBL7465125 | 0.85 | HTR1A (0.52) | ADRA2AADRA2BADRA2CHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876372-A1 | HETEROARYLCARBOXAMIDE DERIVATIVES | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997023485-A1 | HETEROARYLCARBOXAMIDE DERIVATIVES | KNOLL AKTIENGESELLSCHAFT (DE) | 1997-07-03 | — | — | WO | disclosed |