Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.51 |
| ▸ | DRD2 | P14416 | 7/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7467130 | 1.00 | HTR1A (0.51) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL7465933 | 0.88 | ADRA1D (0.46) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL7467649 | 0.87 | HTR1A (0.48) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL7469846 | 0.87 | HTR1A (0.48) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL7464370 | 0.86 | HTR1A (0.46) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL8557296 | 0.86 | ADRA2A (0.50) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL7461438 | 0.86 | HTR1A (0.56) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL7463410 | 0.86 | HTR1A (0.52) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL7472103 | 0.85 | HTR1A (0.54) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL7468996 | 0.85 | HTR1A (0.46) | HTR1ADRD2ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876372-B1 | HETEROARYLCARBOXAMIDE DERIVATIVES | KNOLL GMBH (DE) | 2002-03-06 | — | — | EP | claimed |
| US-6107310-A | PSYCHOLOGICAL DISORDERS | KNOLL AKTIENGESELLSCHAFT (DE) | 2000-08-22 | — | — | US | claimed |
| EP-0876372-B1 | HETEROARYLCARBOXAMIDE DERIVATIVES | KNOLL GMBH (DE) | 2002-03-06 | — | — | EP | disclosed |
| US-6107310-A | PSYCHOLOGICAL DISORDERS | KNOLL AKTIENGESELLSCHAFT (DE) | 2000-08-22 | — | — | US | disclosed |