Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.47 |
| ▸ | PDE9A | O76083 | 2/20 | 0.47 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557199 | 0.88 | PDE5A (0.43) | PDE5APDE9AKDM4EALDH1A1HPGD | |
| SCHEMBL8557418 | 0.85 | PDE5A (0.49) | PDE5APDE9AMEN1KMT2AMAPT | |
| SCHEMBL8555764 | 0.85 | PDE5A (0.49) | PDE5APDE9ANPBWR1MEN1KMT2A | |
| SCHEMBL8557015 | 0.82 | PDE9A (0.47) | PDE5APDE9AMEN1KMT2AMAPT | |
| SCHEMBL8553493 | 0.80 | PDE9A (0.58) | PDE5APDE9ANPBWR1MEN1KMT2A | |
| SCHEMBL8554950 | 0.80 | PDE5A (0.44) | PDE5APDE9AKDM4EALDH1A1HPGD | |
| SCHEMBL8558570 | 0.77 | KDM4E (0.48) | PDE5APDE9AKMT2AMAPTCYP1A2 | |
| SCHEMBL8558977 | 0.75 | PDE5A (0.38) | PDE5APDE9AMGLL | |
| SCHEMBL8557499 | 0.74 | PDE5A (0.46) | PDE5APDE9AMEN1KMT2ATNKS | |
| SCHEMBL8553369 | 0.73 | PDE5A (0.45) | PDE5APDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691970-B1 | IMIDAZOLOQUINOXALINONE DERIVATIVES AS EAA ANTAGONISTS | BASF AG (DE) | 1998-11-11 | — | — | EP | claimed |
| EP-0691970-B1 | IMIDAZOLOQUINOXALINONE DERIVATIVES AS EAA ANTAGONISTS | BASF AG (DE) | 1998-11-11 | — | — | EP | disclosed |