Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30349741 | 0.88 | KCNH2 (0.39) | KMT2ALMNAALDH1A1MAPTHPGD | |
| SCHEMBL5672147 | 0.84 | — | — | |
| SCHEMBL1615519 | 0.84 | OPRM1 (0.31) | SLC6A3DPP4 | |
| SCHEMBL181625 | 0.82 | ALDH1A1 (0.39) | KMT2ALMNAALDH1A1MAPTHPGD | |
| SCHEMBL3585121 | 0.79 | DPP7 (0.41) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL936325 | 0.77 | KMT2A (0.38) | KMT2ALMNAALDH1A1MAPTHPGD | |
| SCHEMBL16919618 | 0.77 | KMT2A (0.39) | KMT2ALMNAALDH1A1MAPTHPGD | |
| SCHEMBL9738640 | 0.77 | KMT2A (0.39) | KMT2ALMNAALDH1A1MAPTHPGD | |
| SCHEMBL486412 | 0.77 | DPP7 (0.44) | MAPTNPSR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL935001 | 0.76 | KMT2A (0.36) | KMT2ALMNAALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106083850-B | A kind of pyrimido naphthalimide derivative and its preparation method and application | 河南大学 | 2018-01-02 | — | — | CN | disclosed |
| CN-106083850-A | One class pyrimido naphthalimide derivative and its preparation method and application | 河南大学 | 2016-11-09 | — | — | CN | disclosed |
| EP-0575954-B1 | Aminoalkylcarbamic esters of eseroline suitable for use as cholinesterase acitivity inhibitors and relative preparation process | MEDIOLANUM FARMACEUTICI SRL (IT) | 1998-09-02 | — | — | EP | disclosed |
| US-5424451-A | Used as cholinesterase activity inhibitors | MEDIOLANUM FARMACEUTICI S.P.A. (IT) | 1995-06-13 | — | — | US | disclosed |
| US-5302593-A | Aminoalkylcarbamic esters of eseroline suitable for use as chlorinesterase activity inhibitors | MEDIOLANUM FARMACEUTICI S.P.A. (IT) | 1994-04-12 | — | — | US | disclosed |
| EP-0575954-A1 | Aminoalkylcarbamic esters of eseroline suitable for use as cholinesterase acitivity inhibitors and relative preparation process | MEDIOLANUM FARMACEUTICI S.P.A. (IT) | 1993-12-29 | — | — | EP | disclosed |