Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557810 | 1.00 | KEAP1 (0.48) | KEAP1SMN1; SMN2LMNAKDM4EHPGD | |
| SCHEMBL8557309 | 1.00 | KEAP1 (0.48) | KEAP1SMN1; SMN2LMNAKDM4EHPGD | |
| SCHEMBL8555711 | 1.00 | KEAP1 (0.48) | KEAP1SMN1; SMN2LMNAKDM4EHPGD | |
| SCHEMBL8558962 | 0.98 | KEAP1 (0.50) | KEAP1SMN1; SMN2LMNAKDM4EHPGD | |
| SCHEMBL8557174 | 0.93 | KEAP1 (0.52) | KEAP1SMN1; SMN2LMNAKDM4EHPGD | |
| SCHEMBL8557571 | 0.85 | KEAP1 (0.45) | KEAP1SMN1; SMN2LMNAKDM4EHPGD | |
| SCHEMBL8556859 | 0.84 | HRH3 (0.52) | SMN1; SMN2LMNAALDH1A1SIGMAR1 | |
| SCHEMBL8558418 | 0.82 | HRH3 (0.56) | SMN1; SMN2ALDH1A1SIGMAR1 | |
| SCHEMBL9740021 | 0.77 | KEAP1 (0.68) | KEAP1SMN1; SMN2KDM4EHPGDDUSP3 | |
| SCHEMBL9738476 | 0.77 | KEAP1 (0.68) | KEAP1SMN1; SMN2KDM4EHPGDDUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0575954-B1 | Aminoalkylcarbamic esters of eseroline suitable for use as cholinesterase acitivity inhibitors and relative preparation process | MEDIOLANUM FARMACEUTICI SRL (IT) | 1998-09-02 | — | — | EP | disclosed |