Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558528 | 0.83 | HTR1A (0.42) | NPC1GAAALDH1A1HTTHTR1A | |
| SCHEMBL8557463 | 0.75 | HTR1A (0.35) | GAAHTR1ADRD2HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL8556678 | 0.75 | HTR1A (0.34) | GAAHTR1ADRD2HTR2AHTR2C | |
| SCHEMBL8556686 | 0.64 | HTR1A (0.45) | NPC1GAAALDH1A1HTTHTR1A | |
| Hydrochloric Acid SCHEMBL8556291 | 0.64 | HTR1A (0.45) | NPC1GAAALDH1A1HTTHTR1A | |
| Hydrochloric Acid SCHEMBL8557929 | 0.64 | HTR1A (0.37) | GAAHTR1ADRD2HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL9095615 | 0.64 | KDM4E (0.38) | NPC1GAAPOLBALDH1A1KDM4E | |
| SCHEMBL9095407 | 0.62 | ADRB2 (0.36) | GAAALDH1A1HTR2AHTR2CKDM4E | |
| SCHEMBL9097387 | 0.61 | ADRB2 (0.41) | ALDH1A1HTR2AHTR2CKDM4EHPGD | |
| Hydrochloric Acid SCHEMBL9094427 | 0.61 | ADRB2 (0.36) | ALDH1A1HTR2AHTR2CKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653426-B1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA CO (JP) | 1998-07-22 | — | — | EP | disclosed |
| US-5510366-A | INOTROPIC, ANTIARRHYMTHMIA AGENTS, VASODILATORS | KOWA CO., LTD. (JP) | 1996-04-23 | — | — | US | disclosed |
| EP-0653426-A1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA COMPANY, LTD. (JP) | 1995-05-17 | — | — | EP | disclosed |