Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 7/20 | 0.38 |
| ▸ | MMP2 | P08253 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557646 | 0.83 | NPC1 (0.33) | HTR1ADRD2HTR2AHTR2CHTR2B | |
| SCHEMBL8556686 | 0.82 | HTR1A (0.45) | HTR1ADRD2HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL8556291 | 0.81 | HTR1A (0.45) | HTR1ADRD2HTR2AHTR2CHTR2B | |
| SCHEMBL11747833 | 0.68 | RAB9A (0.56) | KDM4ERAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL11745635 | 0.68 | RAB9A (0.59) | KDM4ERAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9093938 | 0.67 | EPHX2 (0.37) | DRD2KDM4ERAB9AALDH1A1HPGD | |
| SCHEMBL13395659 | 0.66 | KDM4E (0.47) | HTR1ADRD2HTR2AHTR2CHTR2B | |
| SCHEMBL6739125 | 0.66 | KDM4E (0.58) | KDM4ERAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL8959852 | 0.65 | KDM4E (0.51) | KDM4ERAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL13395586 | 0.65 | ALDH1A1 (0.48) | HTR1ADRD2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653426-B1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA CO (JP) | 1998-07-22 | — | — | EP | disclosed |
| US-5510366-A | INOTROPIC, ANTIARRHYMTHMIA AGENTS, VASODILATORS | KOWA CO., LTD. (JP) | 1996-04-23 | — | — | US | disclosed |
| EP-0653426-A1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA COMPANY, LTD. (JP) | 1995-05-17 | — | — | EP | disclosed |