Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 3/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 8/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GBA2 | Q9HCG7 | 12/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560402 | 0.83 | S1PR1 (0.41) | S1PR1S1PR3S1PR5S1PR4GBA1 | |
| SCHEMBL27991953 | 0.79 | S1PR1 (0.35) | S1PR1S1PR3S1PR5S1PR4GBA1 | |
| SCHEMBL27991957 | 0.77 | LTA4H (0.41) | S1PR1S1PR3S1PR5GBA1 | |
| SCHEMBL27977764 | 0.77 | HRH3 (0.33) | S1PR1S1PR3S1PR5CYP3A4CYP2D6 | |
| SCHEMBL27978078 | 0.75 | LTA4H (0.39) | S1PR1S1PR3S1PR5TSHRSMN1; SMN2 | |
| SCHEMBL27977767 | 0.73 | GBA1 (0.35) | S1PR1S1PR3S1PR5S1PR4GBA1 | |
| SCHEMBL20878453 | 0.73 | S1PR1 (0.65) | S1PR1S1PR3S1PR5S1PR4GBA1 | |
| SCHEMBL11775355 | 0.73 | S1PR1 (0.32) | S1PR1S1PR3S1PR5GBA1 | |
| SCHEMBL24428807 | 0.72 | S1PR1 (0.59) | S1PR1S1PR3S1PR5S1PR4GBA1 | |
| SCHEMBL5533905 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0853615-A1 | PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 1998-07-22 | — | — | EP | disclosed |
| WO-1997010212-A1 | PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 1997-03-20 | — | — | WO | disclosed |